🔬

Yongkuk Park

Postdoctoral Research Fellow
Brigham and Women’s Hospital
Harvard Medical School
Wyss Institute

Contact
📧 Email: ypark21@bwh.harvard.edu
LinkedIn: Yongkuk Park

💡

I am a Postdoctoral Research Fellow in the Artzi Lab at Brigham and Women's Hospital and Harvard Medical School, where my research focuses on engineering nanocarrier-based platforms for cancer immunotherapy and tissue regeneration. I received my Ph.D. in Chemical Engineering with a specialization in bone tissue engineering, during which I developed advanced in vitro bone tissue models to recapitulate the complexity of human bone physiology. My current work integrates biomaterial engineering, nanomedicine, and tumor immunology, with a particular focus on leveraging innate immune activation strategies to improve therapeutic outcomes. I am passionate about bridging fundamental biology with translational engineering to develop next-generation therapeutic platforms.

🔬 Research Interest

  • Immunotherapy
  • Tissue engineering - In vitro tissue model
  • Mechanotransduction, Mechanobiology - Device fabrication for mechanical cell culture
  • Bone regeneration, regenerative medicine
  • Nucleic acid-based drug delivery

🎓 Education

  • Ph.D., Chemical Engineering, University of Massachusetts Amherst (2022)

    Advised by Jungwoo Lee

    (Thesis Title: Development of in vitro bone organoid models for the recapitulation of bone complexity)

  • M.S., Chemical Engineering, University of Seoul, South Korea, (2016)

    Advised by Jong Bum Lee

    (Thesis Title: Step-wise dual enzyme polymerization (SDEP) for fabrication of DNA-RNA hybridization-based structures)

  • B.S., Chemical Engineering, University of Seoul, South Korea, (2014)

📊 Publications | Google Scholar

2026

Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis
A Choi, JY Lee, H Yoon, X Che, M Choi, Yongkuk Park, K Shin, H Lee, J Park, ...
Bone Research 14 (1), 37

2024

2023

2021

Trabecular bone organoid model for studying the regulation of localized bone remodeling
Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee
Science Advances

2020

Double Controlled Release of Therapeutic RNA Modules through Injectable DNA–RNA Hybrid Hydrogel
Sangwoo Han, Yongkuk Park, Hyejin Kim, Hyangsu Nam, Ohsung Ko, Jong Bum Lee
ACS Applied Materials & Interfaces

~2016

Self-assembled DNA-guided RNA Nanovector via Step-wise Dual Enzyme Polymerization (SDEP) for Carrier-free siRNA Delivery
Yongkuk Park, Hyejin Kim, Jong Bum Lee
ACS Biomaterials Science & Engineering (2016)

Technological development of structural DNA/RNA-based RNAi systems and their applications
Eun Hye Jeong, Hyejin Kim, Bora Jang, Hyesoo Cho, Jaehee Ryu, Boyeon Kim, Yongkuk Park, Jieun Kim, Jong Bum Lee, Hyukjin Lee Advanced Drug Delivery Reviews (2016)